Functions

Network Functions

Functions for reconstruction, community detection and plotting of methylation multiplex.

meNet_cor()

CpG network: edges based on correlation

meNet_singleCGI()

CpG network for a single CpG island

meNet_CGI()

CpG network: edges are based on CpG island affiliation

meNet_singleGene()

CpG network for a single gene

meNet_gene()

CpG network: edges are based on gene affiliation

meMultiplex()

Multiplex: `meNet` file from two `igraph` layers

meMultiplex_communities()

Multiplex community structure

meMultiplex_to_multinet()

Multiplex: `meNet` file to `multinet` object

plot_multiplex()

Multiplex plot

Resampling Functions

Functions which estimate the variability of correlation and calculte p-value of the correlation permutation test.

cor_resamplingStats()

Mean and standard deviation of correlation

cor_permutationTest()

Correlation permutation test

Methylation Plot Functions

Beta value error plots which use CpG coordinates to position them on x-axis.

plotCI_meCpG()

Beta value error plot with CpG coordinates

plotCI_meCGI()

Beta value error plot for a CpG island

Other Functions

Secondary functions mostly called from the main functions.

boxed_heatmap()

Heat map without the use of `layout` function

CpG_in_CGI()

CpGs within a CpG island

find_CpG()

CpG coordinates on a chromosome

read_infomap_communities()

Multiplex community structure from file

coord_sort()

Sorting CpGs by coordinate

max_normalization()

Maximum normalization

neg_max_normalization()

Negative maximum normalization

Data

Description Tables

Data frames that contain information about methylation and genomic data.

CpG_annoHM450K

Description of HM450K CpG sites

CpG_genes

Genes associated with HM450K CpG sites

UCSC_CGI

UCSC CpG islands

UCSC_genes

UCSC transcripts

N_ranges

Unsequences genome

Methylation Data

Examples of methylation data set to be used to test the functionalities of the package.

Bacalini_betaValues

Bacalini HM450K methylation data

Bacalini_sampleSheet

Bacalini sample sheet

Johansson_residuals

Johansson HM450K methylation data