Johansson_residuals.RdMethylation values based on the data set obtained by Johansson et al. (Johansson et al. 2013) . Methylation beta values for 728 healthy samples were obtained with Illumina HM450K microarray. In the step of data preparation and preprocessing, problematic CpGs were removed and the original beta values were adjusted for age, sex and cell counts. `meNet::Johansson_residuals` data frame contains the residuals of the preprocessing analysis for chromosome 21.
Johansson_residuals
A data frame with 3536 rows and 728 columns. Row names are unique CpG identifiers from the Illumina CG database.
Original data set was downloaded from the Gene Expression Omnibus (GEO) data repository as a data set with accession number GSE87571 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE87571.
Some CpG sites from chromosome 21 are not included. They may be omitted in the original data set or removed during the preprocessing. Moreover, CpG sites are the same as in the `meNet::Bacalini_betaValues` data set and thus only the intersection of measured CpGs remains.
Johansson \, Enroth S, Gyllensten U (2013). “Continuous aging of the human DNA methylome throughout the human lifespan.” PloS one, 8(6), e67378.